Separation of vigabatrin enantiomers using mixed-mode chromatography and its application to determine the vigabatrin enantiomer levels in rat plasma

Onozato, M; Uekusa, S; Sakamoto, T; Umino, M; Ichiba, H; Fukushima, T

Fukushima, T (corresponding author), Toho Univ, Fac Pharmaceut Sci, Dept Analyt Chem, 2-2-1 Miyama, Funabashi, Chiba 2748510, Japan.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021; 1179 ():

Abstract

Mixed-mode chromatography-comprising a mixed phase with reversed and ionic phases, enabling hydrophobic and ion-exchange interactions simultaneously-w......

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