MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis

Xu, D; Yao, MH; Wang, YQ; Yuan, L; Hoeck, JD; Yu, JW; Liu, L; Yeap, YYC; Zhang, WY; Zhang, F; Feng, YH; Ma, TT; Wang, YJ; Ng, DCH; Niu, XY; Su, B; Behrens, A; Xu, ZH

Xu, ZH (reprint author), Chinese Acad Sci, Inst Genet & Dev Biol, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Mol Dev Biol, Beijing, Peoples R China.; Xu, ZH (reprint author), Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples

PLOS BIOLOGY, 2018; 16 (12):

Abstract

Mutations of WD repeat domain 62 (WDR62) lead to autosomal recessive primary microcephaly (MCPH), and down-regulation of WDR62 expression causes the l......

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