Structural and Mechanistic Insights into Mycobacterium abscessus Aspartate Decarboxylase PanD and a Pyrazinoic Acid-Derived Inhibitor

Saw, WG; Leow, CY; Harikishore, A; Shin, J; Cole, MS; Aragaw, WW; Ragunathan, P; Hegde, P; Aldrich, CC; Dick, T; Gruber, G

Gruber, G (通讯作者)，Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore.;Aldrich, CC (通讯作者)，Univ Minnesota, Coll Pharm, Dept Med Chem, Minneapolis, MN 55455 USA.;Dick, T (通讯作者)，Hackensack Meridian Hlth, Ctr Discovery & Innovat, Nutley, NJ 07110 USA.;Dick, T (通讯作者)，Georgetown Univ, Dept Microbiol & Immunol, Washington, DC 20007 USA.;Dick, T (通讯作者)，Hackensack Meridian Sch Med, Dept Med Sci, Nutley, NJ 07110 USA.

ACS INFECTIOUS DISEASES, 2022; 8 (7): 1324

Abstract

ABSTRACT: Mycobacterium tuberculosis (Mtb) aspartate decarboxylase PanD is required for biosynthesis of the essential cofactor coenzyme A and targeted......

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