The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production

Sausville, LN; Gangadhariah, MH; Chiusa, M; Mei, SJ; Wei, SZ; Zent, R; Luther, JM; Shuey, MM; Capdevila, JH; Falck, JR; Guengerich, FP; Williams, SM; Pozzi, A

Pozzi, A (reprint author), Vanderbilt Univ, Sch Med, Med Ctr North,B3115, Nashville, TN 37232 USA.

CANCER RESEARCH, 2018; 78 (17): 4865

Abstract

Increased expression of cytochrome P450 CYP2C9, together with elevated levels of its products epoxyeicosatrienoic acids (EET), is associated with aggr......

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