PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing

Fong, KW; Zhao, JC; Lu, XD; Kim, J; Piunti, A; Shilatifard, A; Yu, JD

Yu, JD (通讯作者)，Northwestern Univ, Dept Med, Div Hematol Oncol, Feinberg Sch Med, Chicago, IL 60611 USA.;Yu, JD (通讯作者)，Northwestern Univ, Feinberg Sch Med, Simpson Querrey Inst Epigenet, Dept Biochem & Mol Genet, Chicago, IL 60611 USA.;Yu, JD (通讯作者)，Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 USA.

MOLECULAR CELL, 2022; 82 (24): 4611

Abstract

PALI1 is a newly identified accessory protein of the Polycomb repressive complex 2 (PRC2) that catalyzes H3K27 methylation. However, the roles of PALI......

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