Spatiotemporal feedforward between PKM2 tetramers and mTORC1 prompts mTORC1 activation

Xia, Y; Wang, SM; Song, CB; Luo, RY

Luo, RY (通讯作者)，Fudan Univ, Human Phenome Inst, Shanghai 200433, Peoples R China.;Luo, RY (通讯作者)，Fudan Univ, Acad Engn & Technol, Shanghai 200433, Peoples R China.;Luo, RY (通讯作者)，Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China.;Luo, RY (通讯作者)，Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai 200433, Peoples R China.

PHYSICAL BIOLOGY, 2022; 19 (4):

Abstract

Most mammalian cells couple glucose availability to anabolic processes via the mTORC1 pathway. However, the mechanism by which fluctuations in glucose......

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