Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition

Shu, Z; Li, Z; Huang, HH; Chen, Y; Fan, J; Yu, L; Wu, ZH; Tian, L; Qi, Q; Peng, S; Wei, CY; Xie, ZQ; Li, XB; Feng, Q; Sheng, H; Li, GQ; Wei, DP; Shan, CL; Chen, G

Chen, G (corresponding author), Jinan Univ, Sch Med, Dept Med Biochem & Mol Biol, Guangzhou 510632, Peoples R China.

ONCOGENE, 2020; 39 (35): 5721

Abstract

Ribonucleotide reductase (RNR) catalyzes the rate-limiting step of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs) building blocks for ......

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