SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K

Wells, C; Counago, RM; Limas, JC; Almeida, TL; Cook, JG; Drewry, DH; Elkins, JM; Gileadi, O; Kapadia, NR; Lorente-Macias, A; Pickett, JE; Riemen, A; Ruela-de-Sousa, RR; Willson, TM; Zhang, CY; Zuercher, WJ; Zutshi, R; Axtman, AD

Axtman, AD (corresponding author), UNC CH, UNC Eshelman Sch Pharm, SGC, Chapel Hill, NC 27599 USA.; Axtman, AD (corresponding author), UNC CH, UNC Eshelman Sch Pharm, Div Chem Biol & Med Chem, Chapel Hill, NC 27599 USA.

ACS MEDICINAL CHEMISTRY LETTERS, 2020; 11 (3): 340

Abstract

Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual AAK1/BMP2K inhibitors. Optimization furnished a small molecul......

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