Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic Gcn2 Expression

Yin, HR; Yuan, FX; Jiao, FX; Niu, YG; Jiang, XX; Deng, JL; Guo, YJ; Chen, SH; Zhai, QW; Hu, C; Li, YM; Guo, FF

Guo, FF (通讯作者)，Univ Chinese Acad Sci, Key Lab Nutr Metab & Food Safety, Innovat Ctr Intervent Chron Dis & Promot Hlth, Shanghai Inst Nutr & Hlth,Chinese Acad Sci, Beijing, Peoples R China.;Hu, C; Guo, FF (通讯作者)，Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Shanghai, Peoples R China.;Hu, C (通讯作者)，Shanghai Diabet Inst, Shanghai Clin Ctr Diabet, Shanghai Key Lab Diabet Mellitus, Shanghai, Peoples R China.;Hu, C (通讯作者)，Southern Med Univ, Inst Metab Dis, Fengxian Cent Hosp, Shanghai, Peoples R C

DIABETES, 2022; 71 (2): 206

Abstract

Leucine deprivation improves insulin sensitivity; however, whether and how this effect can be extended are unknown. We hypothesized that intermittent ......

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