Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies

Harlow, CE; Gandawijaya, J; Bamford, RA; Martin, ER; Wood, AR; van der Most, PJ; Tanaka, T; Leonard, HL; Etheridge, AS; Innocenti, F; Beaumont, RN; Tyrrell, J; Nalls, MA; Simonsick, EM; Garimella, PS; Shiroma, EJ; Verweij, N; Meer, P; Gansevoort, RT; Snieder, H; Gallins, PJ; Jima, DD; Wright, F; Zhou, YH; Ferrucci, L; Bandinelli, S; Hernandez, DG; van der Harst, P; Patel, VV; Waterworth, DM; Chu, AY; Oguro-Ando, A; Frayling, TM

Oguro-Ando, A; Frayling, TM (通讯作者)，Univ Exeter, Univ Exeter Med Sch, Royal Devon & Exeter NHS Trust, Exeter EX2 5DW, Devon, England.

AMERICAN JOURNAL OF HUMAN GENETICS, 2022; 109 (9): 1638

Abstract

Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are currently under clinical development for treating anemia in chronic kidney disea......

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