LPA/LPAR1 signaling induces PGAM1 expression via AKT/mTOR/HIF-1 alpha pathway and increases aerobic glycolysis, contributing to keratinocyte proliferation

Kim, D; Khin, PP; Lim, OK; Jun, HS

Jun, HS (通讯作者)，Gachon Univ, Lee Gil Ya Canc & Diabet Inst, 155 Gaetbeol Ro, Incheon 21999, South Korea.;Jun, HS (通讯作者)，Gachon Univ, Coll Pharm, 191 Hambangmoe Ro, Incheon 21936, South Korea.;Jun, HS (通讯作者)，Gachon Univ, Gachon Inst Pharmaceut Sci, 191 Hambangmoe Ro, Incheon 21936, South Korea.

LIFE SCIENCES, 2022; 311 ():

Abstract

Aims: Psoriasis is a chronic inflammatory skin disease and lysophosphatidic acid (LPA) has recently been re-ported to contribute to its pathogenesis t......

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