Parkin Insufficiency Accentuates High-Fat Diet-Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload

Wu, NN; Bi, YG; Ajoolabady, A; You, F; Sowers, J; Wang, QR; Ceylan, AF; Zhang, YM; Ren, J

Ren, J (通讯作者)，Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai 200032, Peoples R China.;Zhang, YM (通讯作者)，Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai 200032, Peoples R China.

JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (8): 779

Abstract

Mitochondrial Ca2+ overload contributes to obesity cardiomyopathy, yet mechanisms that directly regulate it remain elusive. The authors investigated t......

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