CTLA-4 antibody ipilimumab negatively affects CD4(+) T-cell responses in vitro-MedSci.cn

CTLA-4 antibody ipilimumab negatively affects CD4(+) T-cell responses in vitro

Rosskopf, S; Leitner, J; Zlabinger, GJ; Steinberger, P

Steinberger, P (reprint author), Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Inst Immunol, Div Immune Receptors & T Cell Activat, Lazarettgasse 19, Vienna, Austria.

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2019; 68 (8): 1359

Abstract

Immune checkpoint inhibitors targeting coinhibitory pathways in T cells possess efficacy in combating cancer. In addition to PD-1/PD-L1 and CTLA-4 ant......

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