Discovery of High-Affinity Inhibitors of the BPTF Bromodomain

Lu, T; Lu, HB; Duan, Z; Wang, J; Han, J; Xiao, SH; Chen, HH; Jiang, H; Chen, Y; Yang, F; Chen, DY; Lin, J; Li, B; Jiang, HL; Chen, KX; Lu, WC; Lin, H; Luo, C

Luo, C (corresponding author), Fujian Med Univ, Sch Pharm, Fuzhou, Peoples R China.; Luo, C (corresponding author), Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China.; Luo, C (corresponding author), Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China.; Lin, H; Luo, C (corresponding author), Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Design & Discovery Ctr,Chem Biol Ctr, Shanghai 201203, Peoples R China.; Lu, WC (corresponding author), S

JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (16): 12075

Abstract

The dysfunctional bromodomain PHD finger transcription factor (BPTF) exerts a pivotal influence in the occurrence and development of many human diseas......

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