Activation of the beta-TrCP/I kappa B alpha/inflammation axis limits the sensitivity of liver cancer cells to neddylation inhibition

Xiong, HJ; Zheng, DD; Liu, Y; Ma, LH; Meng, LZ; Yang, ZZ; Yang, ZX

Yang, ZX (通讯作者)，Chongqing Tradit Chinese Med Hosp, Dept Oncol, 6 Panxi St,Seven Branch Rd, Chongqing 400016, Jiangbei, Peoples R China.;Yang, ZZ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Canc Ctr, 288 Tianwen Ave, Chongqing 400010, Peoples R China.

ONCOLOGY REPORTS, 2022; 48 (5):

Abstract

Upregulation of protein neddylation occurs in numerous types of human cancer, including liver cancer. MLN4924, a potent neddylation-inhibiting pharmac......

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