Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

Hammill, JT; Scott, DC; Min, J; Connelly, MC; Holbrook, G; Zhu, FY; Matheny, A; Yang, L; Singh, B; Schulman, BA; Guy, RK

Guy, RK (reprint author), St Jude Childrens Res Hosp, Dept Chem Biol & Theraput, 332 N Lauderdale St, Memphis, TN 38105 USA.; Guy, RK (reprint author), Univ Kentucky, Dept Pharmaceut Sci, 789 South Limestone, Lexington, KY 40508 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2018; 61 (7): 2680

Abstract

We previously discovered and validated a class of piperidinyl ureas that regulate defective in cullin neddylation 1 (DCN1)-dependent neddylation of cu......

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