Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding

Grädler, U; Schwarz, D; Wegener, A; Eichhorn, T; Bandeiras, TM; Freitas, MC; Lammens, A; Ganichkin, O; Augustin, M; Minguzzi, S; Becker, F; Bomke, J

Grädler, U (通讯作者),Healthcare Business Merck KGaA, Darmstadt, Germany.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (11):

Abstract

The receptor tyrosine kinase MET is activated by hepatocyte growth factor binding, followed by phosphorylation of the intracellular kinase domain (KD)......

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