Immunoproteasome inhibition and bioactivity of thiasyrbactins

Bakas, NA; Schultz, CR; Yco, LP; Roberts, CC; Chang, CEA; Bachmann, AS; Pirrung, MC

Pirrung, MC (reprint author), Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA.; Bachmann, AS (reprint author), Michigan State Univ, Coll Human Med, Dept Pediat & Human Dev, Grand Rapids, MI 49503 USA.

BIOORGANIC & MEDICINAL CHEMISTRY, 2018; 26 (2): 401

Abstract

A family of macrodilactam natural products, the syrbactins, are known proteasome inhibitors. A small group of syrbactin analogs was prepared with a su......

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