New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model

Luszczki, JJ; Marzeda, P; Gut-Lepiech, A; Kondrat-Wrobel, MW; Wroblewska-Luczka, P; Karwan, S; Plech, T

Luszczki, JJ (reprint author), Med Univ, Dept Pathophysiol, Lublin, Poland.; Luszczki, JJ (reprint author), Inst Rural Hlth, Isobolog Anal Lab, Lublin, Poland.

PHARMACOLOGICAL REPORTS, 2019; 71 (2): 299

Abstract

Background: To assess the effects of 5-(3-chlorobenzyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (TP427) on the protective anticonvulsant action......

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