Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

Kennedy, A; Waters, E; Rowshanravan, B; Hinze, C; Williams, C; Janman, D; Fox, TA; Booth, C; Pesenacker, AM; Halliday, N; Soskic, B; Kaur, S; Qureshi, OS; Morris, EC; Ikemizu, S; Paluch, C; Huo, JD; Davis, SJ; Boucrot, E; Walker, LSK; Sansom, DM

Sansom, DM (通讯作者)，UCL Inst Immun & Transplantat, London, England.

NATURE IMMUNOLOGY, 2022; 23 (9): 1365

Abstract

CD28 and CTLA-4 (CD152) play essential roles in regulating T cell immunity, balancing the activation and inhibition of T cell responses, respectively.......

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