Transient expansion of TP53 mutated clones in polycythemia vera patients treated with idasanutlin

Marcellino, BK; Farnoud, N; Cassinat, B; Lu, M; Verger, E; McGovern, E; Patel, M; Medina-Martinez, J; Levine, MF; Ossa, JEA; Zhou, YY; Kosiorek, H; Mehrotra, M; Houldsworth, J; Dueck, A; Rossi, M; Mascarenhas, J; Kiladjian, JJ; Rampal, RK; Hoffman, R

Hoffman, R (corresponding author), Mem Sloan Kettering Canc Ctr, 1 Gustave L Levy Pl,Box 1079, New York, NY 10029 USA.

BLOOD ADVANCES, 2020; 4 (22): 5735

Abstract

Activation of the P53 pathway through inhibition of MDM2 using nutlins has shown clinical promise in the treatment of solid tumors and hematologic mal......

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