Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design

Maddirala, AR; Klein, R; Pinkner, JS; Kalas, V; Hultgren, SJ; Janetka, JW

Janetka, JW (reprint author), Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA.; Janetka, JW (reprint author), Washington Univ, Sch Med, Dept Mol Microbiol, Ctr Womens Infect Dis Res, St Louis, MO 63110 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2019; 62 (2): 467

Abstract

The F9/Yde/Fml pilus, tipped with the FmlH adhesin, has been shown to provide uropathogenic Escherichia coli (UPEC) a fitness advantage in urinary tra......

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