PU.1 inhibition attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin-II by reducing TGF-beta 1/Smads pathway activation

Hu, J; Zhang, JJ; Li, L; Wang, SL; Yang, HT; Fan, XW; Zhang, LM; Hu, GL; Fu, HX; Song, WF; Yan, LJ; Liu, JJ; Wu, JT; Kong, B

Wu, JT (corresponding author), Zhengzhou Univ, Cent China Fuwai Hosp, Heart Ctr Henan Prov Peoples Hosp, Zhengzhou 450003, Henan, Peoples R China.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2021; 25 (14): 6746

Abstract

Fibrosis serves a critical role in driving atrial remodelling-mediated atrial fibrillation (AF). Abnormal levels of the transcription factor PU.1, a k......

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