Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice

Giaime, E; Tong, YR; Wagner, LK; Yuan, Y; Huang, GD; Shen, J

Shen, J (reprint author), Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA.; Shen, J (reprint author), Harvard Med Sch, Program Neurosci, Boston, MA 02115 USA.

NEURON, 2017; 96 (4): 796

Abstract

LRRK2 mutations are the most common genetic cause of Parkinson's disease, but LRRK2's normal physiological role in the brain is unclear. Here, we show......

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