Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

Zhong, WZ; Rao, ZQ; Xu, J; Sun, Y; Hu, HR; Wang, P; Xia, YX; Pan, XX; Tang, WW; Chen, ZY; Zhou, HM; Wang, XH

Zhou, HM; Wang, XH (通讯作者)，Nanjing Med Univ, Affiliated Hosp 1, Hepatobiliary Liver Transplantat Ctr, Nanjing 210029, Peoples R China.

AGING CELL, 2022; 21 (6):

Abstract

Macrophage-stimulator of interferon genes (STING) signaling mediated sterile inflammation has been implicated in various age-related diseases. However......

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