Discovery of ASP5286: A novel non-immunosuppressive cyclophilin inhibitor for the treatment of HCV

Makino, T; Yoshimura, S; Neya, M; Yamanaka, T; Sawada, M; Tsujii, E; Barrett, D

Makino, T (corresponding author), Astellas Pharma Inc, Drug Discovery Res, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020; 30 (16):

Abstract

Evidence indicates that hepatitis C virus (HCV) utilizes cellular cyclophilin proteins in its replication, and cyclophilin inhibitors represent a new ......

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