FXR-Deoxycholic Acid-TNF-alpha Axis Modulates Acetaminophen-Induced Hepatotoxicity

Yan, TT; Yan, NN; Wang, H; Yagai, T; Luo, YH; Takahashi, S; Zhao, M; Krausz, KW; Wang, GJ; Hao, HP; Gonzalez, FJ

Gonzalez, FJ (corresponding author), NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.; Wang, GJ; Hao, HP (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Key Lab Drug Metab & Pharmacokinet, Nanjing 210009, Jiangsu, Peoples R China.

TOXICOLOGICAL SCIENCES, 2021; 181 (2): 273

Abstract

The idiosyncratic characteristics and severity of acetaminophen (APAP) overdose-induced hepatotoxicity render identifying the predisposing factors and......

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