Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology

Nana, AL; Sidhu, M; Gaus, SE; Hwang, JHL; Li, LB; Park, Y; Kim, EJ; Pasquini, L; Allen, IE; Rankin, KP; Toller, G; Kramer, JH; Geschwind, DH; Coppola, G; Huang, EJ; Grinberg, LT; Miller, BL; Seeley, WW

Seeley, WW (reprint author), Univ Calif San Francisco, Dept Neurol, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA.; Seeley, WW (reprint author), Univ Calif San Francisco, Dept Pathol & Lab Med, San Francisco, CA 94143 USA.

ACTA NEUROPATHOLOGICA, 2019; 137 (1): 27

Abstract

TAR DNA-binding protein 43 (TDP-43) aggregation is the most common pathological hallmark in frontotemporal dementia (FTD) and characterizes nearly all......

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