Myeloid Cell-associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing

Wang, L; Sfakianos, JP; Beaumont, KG; Akturk, G; Horowitz, A; Sebra, RP; Farkas, AM; Gnjatic, S; Hake, A; Izadmehr, S; Wiklund, P; Oh, WK; Szabo, PM; Wind-Rotolo, M; Unsal-Kacmaz, K; Yao, X; Schadt, E; Sharma, P; Bhardwaj, N; Zhu, J; Galsky, MD

Zhu, J (corresponding author), Icahn Sch Med Mt Sinai, Icahn Inst Data Sci & Genom Technol, New York, NY 10029 USA.; Zhu, J (corresponding author), Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.; Zhu, J (corresponding author), Sema4, Stamford, CT USA.; Bhardwaj, N (corresponding author), Icahn Sch Med Mt Sinai, Precis Immunol Inst, New York, NY 10029 USA.; Bhardwaj, N (corresponding author), Icahn Sch Med Mt Sinai, Tisch Canc Inst, Dept Med, Div Hematol Oncol, New York,

CLINICAL CANCER RESEARCH, 2021; 27 (15): 4287

Abstract

Purpose To define dominant molecular and cellular features associated with PD-1/PD-L1 blockade resistance in metastatic urothelial cancer. Experimenta......

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