Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

Han, CC; Li, YF; Zhang, YW; Wang, Y; Cui, DQ; Luo, TT; Zhang, Y; Liu, Q; Li, H; Wang, C; Xu, DX; Ma, Y; Wei, W

Ma, Y; Wei, W (corresponding author), Anhui Med Univ, Minist Educ, Inst Clin Pharmacol, Key Lab Antiinflammatory & Immune Med,Anhui Colla, Hefei 230032, Peoples R China.; Xu, DX (corresponding author), Anhui Med Univ, Publ Hlth & Prevent Med Postdoctoral Res Stn, Hefei 230032, Peoples R China.

ACTA PHARMACEUTICA SINICA B, 2021; 11 (7): 1835

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up......

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