Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging

Chen, X; Yang, YZ; Berger, I; Khalid, U; Patel, A; Cai, J; Farwell, MD; Langer, C; Aggarwal, C; Albelda, SM; Katz, SI

Katz, SI (reprint author), Univ Penn, Dept Radiol, Perelman Sch Med, Philadelphia, PA 19104 USA.

ONCOTARGET, 2017; 8 (15): 24213

Abstract

Inhibition of thymidylate synthase (TS) results in a transient "flare" in DNA thymidine salvage pathway activity measurable with FLT ([F-18] thymidine......

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