Gene-based burden analysis of damaging private variants in PRKN, PARK7 and PINK1 in Parkinson's disease cohorts of European descent

Hu, J; Waters, CH; Spiegelman, D; Fon, EA; Yu, E; Asayesh, F; Krohn, L; Saini, P; Alcalay, RN; Hassin-Baer, S; Gan-Or, Z; Krainc, D; Zhang, BR; Bustos, BI; Lubbe, SJ

Zhang, BR (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurol, Hangzhou 310009, Zhejiang, Peoples R China.;Bustos, BI (通讯作者)，Northwestern Univ, Feinberg Sch Med, Ken & Ruth Davee Dept Neurol, 303 E Super St, Chicago, IL 60611 USA.;Bustos, BI (通讯作者)，Northwestern Univ, Feinberg Sch Med, Simpson Querrey Ctr Neurogenet, 303 E Super St, Chicago, IL 60611 USA.

NEUROBIOLOGY OF AGING, 2022; 119 (): 136

Abstract

Recessive mutations in PRKN, PARK7, and PINK1 are established causes of early-onset Parkinson's disease (EOPD). Previous studies have interrogated the......

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