A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin

Leal, LG; Hoggart, C; Jarvelin, MR; Herzig, KH; Sternberg, MJE; David, A

David, A (corresponding author), Imperial Coll London, Dept Life Sci, Ctr Integrat Syst Biol & Bioinformat, London SW7 2AZ, England.

MOLECULAR GENETICS & GENOMIC MEDICINE, 2020; 8 (6):

Abstract

Background Severe hypercholesterolemia (HC, LDL-C > 4.9 mmol/L) affects over 30 million people worldwide. In this study, we validated a new polygen......

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