HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Bobrowicz, M; Dwojak, M; Pyrzynska, B; Stachura, J; Muchowicz, A; Berthel, E; Dalla-Venezia, N; Kozikowski, M; Siernicka, M; Miazek, N; Zapala, P; Domagala, A; Bojarczuk, K; Malenda, A; Barankiewicz, J; Graczyk-Jarzynka, A; Zagozdzon, A; Gabrysiak, M

Golab, J; Winiarska, M (reprint author), Med Univ Warsaw, Dept Immunol, Banacha 1 Str,Block F, PL-02097 Warsaw, Poland.

BLOOD, 2017; 130 (14): 1628

Abstract

Downregulation of CD20, a molecular target for monoclonal antibodies (mAbs), is a clinical problem leading to decreased efficacy of anti-CD20-based th......

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