A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling

Hackney, JA; Shivram, H; Heiden, JV; Overall, C; Orozco, L; Gao, X; Kim, E; West, N; Qamra, A; Chang, DA; Chakrabarti, A; Choy, DF; Combes, AJ; Courau, T; Fragiadakis, GK; Rao, AA; Ray, A; Tsui, JSC; Hu, KN; Kuhn, NF; Krummel, MF; Erle, DJ; Kangelaris, K; Sarma, A; Lyon, Z; Calfee, CS; Woodruff, PG; Ghale, R; Mick, E; Byrne, A; Zha, BS; Langelier, C; Hendrickson, CM; Wijst, MGPV; Hartoularos, GC; Grant, T; Bueno, R; Lee, DS; Greenland, JR; Sun, Y; Perez, R; Ogorodnikov, A; Ward, A; Ye, CJ; Ramalingam, T; Mcbride, JM; Cai, F; Teterina, A; Bao, M; Tsai, LRY; Rosas, IO; Regev, A; Kapadia, SB; Bauer, RN; Rosenberger, CM

Rosenberger, CM (通讯作者),Genentech Inc, 1 DNA Way, South San Francisco, CA 94080 USA.

ISCIENCE, 2023; 26 (10):

Abstract

Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the up regulated EN-RAGE gene program in airway and blo......

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