A genome-engineered bioartificial implant for autoregulated anticytokine drug delivery

Choi, YR; Collins, KH; Springer, LE; Pferdehirt, L; Ross, AK; Wu, CL; Moutos, FT; Harasymowicz, NS; Brunger, JM; Pham, CTN; Guilak, F

Guilak, F (corresponding author), Washington Univ, Dept Orthopaed Surg, St Louis, MO 63110 USA.; Guilak, F (corresponding author), Shriners Hosp Children, St Louis, MO 63110 USA.; Guilak, F (corresponding author), Washington Univ, Ctr Regenerat Med, St Louis, MO 63110 USA.; Guilak, F (corresponding author), Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA.; Guilak, F (corresponding author), Cytex Therapeut Inc, Durham, NC 27704 USA.

SCIENCE ADVANCES, 2021; 7 (36):

Abstract

Biologic drug therapies are increasingly used for inflammatory diseases such as rheumatoid arthritis but may cause significant adverse effects when de......

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