Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity

Fernandez, B; Chittoor-Vinod, VG; Kluss, JH; Kelly, K; Bryant, N; Nguyen, APT; Bukhari, SA; Smith, N; Ordonez, AJL; Fdez, E; Chartier-Harlin, MC; Montine, TJ; Wilson, MA; Moore, DJ; West, AB; Cookson, MR; Nichols, RJ; Hilfiker, S

Nichols, RJ (通讯作者)，Stanford Univ, Dept Pathol, Stanford, CA 94305 USA.;Hilfiker, S (通讯作者)，Rutgers New Jersey Med Sch, Dept Anesthesiol, Newark, NJ 07103 USA.;Hilfiker, S (通讯作者)，Rutgers New Jersey Med Sch, Dept Pharmacol Physiol & Neurosci, Newark, NJ 07103 USA.

JOURNAL OF PARKINSONS DISEASE, 2022; 12 (5): 1423

Abstract

Background: Coding variation in the Leucine rich repeat kinase 2 gene linked to Parkinson's disease (PD) promotes enhanced activity of the encoded LRR......

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