Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159

Konig, S; Romp, E; Krauth, V; Ruhl, M; Dorfer, M; Liening, S; Hofmann, B; Hafner, AK; Steinhilber, D; Karas, M; Garscha, U; Hoffmeister, D; Werz, O

Werz, O (reprint author), Friedrich Schiller Univ Jena, Inst Pharm, Dept Pharmaceut Med Chem, D-07743 Jena, Germany.

CELL CHEMICAL BIOLOGY, 2019; 26 (1): 60

Abstract

5-Lipoxygenase (5-LO) initiates the biosynthesis of pro-inflammatory leukotrienes from arachidonic acid, which requires the nuclear membrane-bound 5-L......

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