A single nucleotide mutation drastically increases the expression of tumor-homing NGR-TNF alpha in the E. coli M15-pQE30 system by improving gene transcription

Chen, J; Yang, H; Feng, YR; Shi, QX; Li, Z; Tao, Z; Fan, J; Jin, YM; Li, SF; Cheng, JQ; Lu, XF

Cheng, JQ; Lu, XF (corresponding author), Sichuan Univ, West China Hosp, Key Lab Transplant Engn & Immunol, MOH,Regenerat Med Res Ctr, Chengdu 610041, Peoples R China.; Cheng, JQ; Lu, XF (corresponding author), Frontiers Sci Ctr Dis Related Mol Network, Chengdu 610041, Peoples R China.; Lu, XF (corresponding author), Sichuan Prov Engn Lab Pathol Clin Applicat, Chengdu 610041, Peoples R China.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2021; 105 (4): 1447

Abstract

Due to their potent immune stimulation, tumor necrosis factor alpha (TNF alpha) variants with tumor-homing activity are attractive as novel antitumor ......

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