Toxicological and bio-distribution profile of a GM-CSF-expressing, double-targeted, chimeric oncolytic adenovirus ONCOS-102-Support for clinical studies on advanced cancer treatment

Kuryk, L; Vassilev, L; Ranki, T; Hemminki, A; Karioja-Kallio, A; Levalampi, O; Vuolanto, A; Cerullo, V; Pesonen, S

Kuryk, L (reprint author), Targovax Oy, Helsinki, Finland.; Kuryk, L (reprint author), Univ Helsinki, Fac Pharm, ImmunoViroTherapy Lab, Div Pharmaceut Biosci, Helsinki, Finland.; Kuryk, L (reprint author), Univ Helsinki, Fac Pharm, Ctr Drug Res, Helsinki,

PLOS ONE, 2017; 12 (8):

Abstract

The purpose of this work was to carry out preclinical toxicity and bio-distribution studies required for regulatory approval of a clinical trial appli......

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