Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice

Tseng, HJ; Chen, WC; Kuo, TF; Yang, G; Feng, CS; Chen, HM; Chen, TY; Lee, TH; Yang, WC; Tsai, KC; Huang, WJ

Huang, WJ (通讯作者),Taipei Med Univ, Coll Pharm, Ph D Program Drug Discovery & Dev Ind, Taipei City, Taiwan.;Yang, WC (通讯作者),Acad Sinica, Agr Biotechnol Res Ctr, 128 Acad Rd Sect 2, Taipei City, Taiwan.;Yang, WC (通讯作者),Natl Taiwan Ocean Univ, Dept Aquaculture, Keelung City, Taiwan.;Yang, WC (通讯作者),Acad Sinica, Translat Biomed Res Ctr, Taipei City, Taiwan.;Yang, WC (通讯作者),Natl Chung Hsing Univ, Dept Life Sci, Taichung, Taiwan.;Tsai, KC (通讯作者),Minist Hlth & Welf, Natl Res Inst Chinese Med, Taipei City, Taiwan.;Yang, WC (通讯作者),China Med Univ, Grad Inst Integrated Med, Taichung, Taiwan.;Huang, WJ (通讯作者),Taipei Med Univ, Grad Inst Pharmacognosy, Coll Pharm, Taipei City, Taiwan.;Huang, WJ (通讯作者),Taipei Med Univ, Coll Pharm, Program Clin Drug Discovery Bot Herbs, Taipei City, Taiwan.;Huang, WJ (通讯作者),Natl Def Med Ctr, Sch Pharm, Taipei City, Taiwan.;Tsai, KC (通讯作者),Taipei Med Univ, Coll Med Sci & Technol, Ph D Program Med Biotechnol, Taipei City, Taiwan.

CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (4):

Abstract

Pdia4 has been characterized as a key protein that positively regulates beta-cell failure and diabetes via ROS regulation. Here, we investigated the f......

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