Synthesis and pharmacokinetic property improvement of deuterated plinabulin 9

Zhao, JC; Cheng, HJ; Sun, TW; Wang, SX; Ding, ZP; Dou, GF; Meng, ZY; Guan, HS; Li, WB

Li, WB (reprint author), Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China.; Li, WB (reprint author), Marine Biomed Res Inst Qingdao, Qingdao 266073, Peoples R China.

JOURNAL OF OCEAN UNIVERSITY OF CHINA, 2017; 16 (2): 305

Abstract

Plinabulin, a potent microtubule-targeting agent, is derived from marine natural diketopiperazine 'phenylahistin'. To develop novel plinabulin analogu......

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