Treating sickle cell disease by targeting HbS polymerization

Eaton, WA; Bunn, HF

Eaton, WA (reprint author), NIDDK, Chem Phys Lab, NIH, Bldg 5,Room 104,9000 Rockville Pike, Bethesda, MD 20892 USA.; Bunn, HF (reprint author), Brigham & Womens Hosp, Med Hematol, 75 Francis St, Boston, MA 02115 USA.

BLOOD, 2017; 129 (20): 2719

Abstract

Although the root cause of sickle cell disease is the polymerization of hemoglobin S (HbS) to form fibers that make red cells less flexible, most drug......

Full Text Link