Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

Zhang, L; Rajbhandari, P; Priest, C; Sandhu, J; Wu, XH; Temel, R; Castrillo, A; Vallim, TQD; Sallam, T; Tontonoz, P

Tontonoz, P (reprint author), Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Pathol & Lab Med, Los Angeles, CA 90024 USA.

ELIFE, 2017; 6 ( ):

Abstract

Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs. Here, we report that RNF145, a previously uncharacterized ER me......

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