Inhibition of Mammalian 15-Lipoxygenase by Three Ebselen-like Drugs. A QM/MM and MM/PBSA Comparative Study

Cebrian-Prats, A; Rovira, T; Saura, P; Gonzalez-Lafont, A; Lluch, JM

Lluch, JM (reprint author), Univ Autonoma Barcelona, Dept Quim, E-08193 Barcelona, Spain.; Lluch, JM (reprint author), Univ Autonoma Barcelona, IBB, E-08193 Barcelona, Spain.

JOURNAL OF PHYSICAL CHEMISTRY A, 2017; 121 (51): 9752

Abstract

Ebselen is a potent competitive inhibitor of the active form of rabbit 15-lipoxygenase, an enzyme involved in many inflammatory diseases. Light-induce......

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