DNA Damage- But Not Enzalutamide-Induced Senescence in Prostate Cancer Promotes Senolytic Bcl-xL Inhibitor Sensitivity

Malaquin, N; Vancayseele, A; Gilbert, S; Antenor-Habazac, L; Olivier, MA; Brahem, ZAA; Saad, F; Delouya, G; Rodier, F

Rodier, F (corresponding author), Ctr Rech Ctr Hosp Univ Montreal CRCHUM, Inst Canc Montreal, Francis Rodier Lab, Montreal, PQ H2X 0A9, Canada.

CELLS, 2020; 9 (7):

Abstract

Cellular senescence is a natural tumor suppression mechanism defined by a stable proliferation arrest. In the context of cancer treatment, cancer cell......

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