Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase

Shen, YY; Sun, F; Zhang, L; Cheng, YJ; Zhu, HR; Wang, SP; Jiao, WH; Leadlay, PF; Zhou, YJ; Lin, HW

Zhou, YJ; Lin, HW (corresponding author), Shanghai Jiao Tong Univ, Res Ctr Marine Drugs, State Key Lab Oncogenes & Related Genes, Dept Pharm,Ren Ji Hosp,Sch Med, Shanghai 200127, Peoples R China.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (16): 5509

Abstract

Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein comp......

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