Intratumoral Plasmid IL12 Expands CD8(+) T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti-PD-1 Therapy-MedSci.cn

Intratumoral Plasmid IL12 Expands CD8(+) T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti-PD-1 Therapy

Telli, ML; Nagata, H; Wapnir, I; Acharya, CR; Zablotsky, K; Fox, BA; Bifulco, CB; Jensen, SM; Ballesteros-Merino, C; Le, MH; Pierce, RH; Browning, E; Hermiz, R; Svenson, L; Bannavong, D; Jaffe, K; Sell, J; Foerter, KM; Canton, DA; Twitty, CG; Osada, T; Lyerly, HK; Crosby, EJ

Telli, ML (corresponding author), Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA.; Crosby, EJ (corresponding author), Duke Med Ctr, Dept Surg, Durham, NC 27710 USA.

Abstract

Purpose: Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Antibodies targeting programmed cell death pr......

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Intratumoral Plasmid IL12 Expands CD8(+) T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti-PD-1 Therapy

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