The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28

Kiontke, KC; Herrera, RA; Vuong, E; Luo, JT; Schwarz, EM; Fitch, DHA; Portman, DS

Fitch, DHA (reprint author), NYU, Dept Biol, Ctr Dev Genet, 100 Washington Sq East, New York, NY 10003 USA.; Portman, DS (reprint author), Univ Rochester, Sch Med & Dent, Dept Biomed Genet & Neurosci, 601 Elmwood Ave, Rochester, NY 14642 USA.; Fitch, DHA

DEVELOPMENTAL CELL, 2019; 49 (4): 542

Abstract

Biological roles for most long non-coding RNAs (lncRNAs) remain mysterious. Here, using forward genetics, we identify lep-5, a lncRNA acting in the C.......

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