EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF

Phan, TH; van Leeuwen, LM; Kuijl, C; Ummels, R; van Stempvoort, G; Rubio-Canalejas, A; Piersma, SR; Jimeanez, CR; van der Sar, AM; Houben, ENG; Bitter, W

Bitter, W (reprint author), Vrije Univ Amsterdam, Amsterdam Inst Mol Med & Syst, Sect Mol Microbiol, Amsterdam, Netherlands.; Bitter, W (reprint author), Amsterdam Univ Med Ctr, Dept Med Microbiol & Infect Control, Amsterdam, Netherlands.

PLOS PATHOGENS, 2018; 14 (8):

Abstract

The pathogen Mycobacterium tuberculosis employs a range of ESX-1 substrates to manipulate the host and build a successful infection. Although the impo......

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